Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

Scott Smemo; Petra Nowotny; Anthony L. Hinrichs; John S.K. Kauwe; Sara Cherny; Katherine Erickson; Amanda J. Myers; Mona Kaleem; Lauren Marlowe; Alison M. Gibson; Paul Hollingworth; Michael C. O'Donovan; Chris M. Morris; Peter Holmans; Simon Lovestone; John C. Morris; Leon Thal; Yonghong Li; Andrew Grupe; John Hardy; Michael J. Owen; Julie Williams; Alison Goate

doi:10.1002/ana.20673

Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

Scott Smemo, Petra Nowotny, Anthony L. Hinrichs, John S.K. Kauwe, Sara Cherny, Katherine Erickson, Amanda J. Myers, Mona Kaleem, Lauren Marlowe, Alison M. Gibson, Paul Hollingworth, Michael C. O'Donovan, Chris M. Morris, Peter Holmans, Simon Lovestone, John C. Morris, Leon Thal, Yonghong Li, Andrew Grupe, John HardyMichael J. Owen, Julie Williams, Alison Goate

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Annals of Neurology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1002/ana.20673
State	Published - Jan 2006
Externally published	Yes

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Smemo, S., Nowotny, P., Hinrichs, A. L., Kauwe, J. S. K., Cherny, S., Erickson, K., Myers, A. J., Kaleem, M., Marlowe, L., Gibson, A. M., Hollingworth, P., O'Donovan, M. C., Morris, C. M., Holmans, P., Lovestone, S., Morris, J. C., Thal, L., Li, Y., Grupe, A., ... Goate, A. (2006). Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology, 59(1), 21-26. https://doi.org/10.1002/ana.20673

@article{0740978621de4d2d92a17088a305398d,

title = "Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease",

abstract = "Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.",

author = "Scott Smemo and Petra Nowotny and Hinrichs, {Anthony L.} and Kauwe, {John S.K.} and Sara Cherny and Katherine Erickson and Myers, {Amanda J.} and Mona Kaleem and Lauren Marlowe and Gibson, {Alison M.} and Paul Hollingworth and O'Donovan, {Michael C.} and Morris, {Chris M.} and Peter Holmans and Simon Lovestone and Morris, {John C.} and Leon Thal and Yonghong Li and Andrew Grupe and John Hardy and Owen, {Michael J.} and Julie Williams and Alison Goate",

year = "2006",

month = jan,

doi = "10.1002/ana.20673",

language = "English",

volume = "59",

pages = "21--26",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Smemo, S, Nowotny, P, Hinrichs, AL, Kauwe, JSK, Cherny, S, Erickson, K, Myers, AJ, Kaleem, M, Marlowe, L, Gibson, AM, Hollingworth, P, O'Donovan, MC, Morris, CM, Holmans, P, Lovestone, S, Morris, JC, Thal, L, Li, Y, Grupe, A, Hardy, J, Owen, MJ, Williams, J & Goate, A 2006, 'Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease', Annals of Neurology, vol. 59, no. 1, pp. 21-26. https://doi.org/10.1002/ana.20673

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T1 - Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

AU - Smemo, Scott

AU - Nowotny, Petra

AU - Hinrichs, Anthony L.

AU - Kauwe, John S.K.

AU - Cherny, Sara

AU - Erickson, Katherine

AU - Myers, Amanda J.

AU - Kaleem, Mona

AU - Marlowe, Lauren

AU - Gibson, Alison M.

AU - Hollingworth, Paul

AU - O'Donovan, Michael C.

AU - Morris, Chris M.

AU - Holmans, Peter

AU - Lovestone, Simon

AU - Morris, John C.

AU - Thal, Leon

AU - Li, Yonghong

AU - Grupe, Andrew

AU - Hardy, John

AU - Owen, Michael J.

AU - Williams, Julie

AU - Goate, Alison

PY - 2006/1

Y1 - 2006/1

N2 - Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.

AB - Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD.

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DO - 10.1002/ana.20673

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SP - 21

EP - 26

JO - Annals of Neurology

JF - Annals of Neurology

IS - 1

ER -

Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease

Abstract

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