Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits

Ina Giegling; Daniel Moreno-De-Luca; Raffaella Calati; Annette M. Hartmann; Hans Jürgen Möller; Diana De Ronchi; Dan Rujescu; Alessandro Serretti

doi:10.1159/000202826

Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits

Ina Giegling, Daniel Moreno-De-Luca, Raffaella Calati, Annette M. Hartmann, Hans Jürgen Möller, Diana De Ronchi, Dan Rujescu, Alessandro Serretti

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.

Original language	English
Pages (from-to)	23-27
Number of pages	5
Journal	Neuropsychobiology
Volume	59
Issue number	1
DOIs	https://doi.org/10.1159/000202826
State	Published - Mar 2009
Externally published	Yes

Keywords

DOPA decarboxylase
Dopaminergic system
Genetics
Personality traits
Tyrosine hydroxylase

Access to Document

10.1159/000202826

Cite this

@article{83648f98991648ba841c4753794b28ad,

title = "Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits",

abstract = "Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.",

keywords = "DOPA decarboxylase, Dopaminergic system, Genetics, Personality traits, Tyrosine hydroxylase",

author = "Ina Giegling and Daniel Moreno-De-Luca and Raffaella Calati and Hartmann, {Annette M.} and M{\"o}ller, {Hans J{\"u}rgen} and {De Ronchi}, Diana and Dan Rujescu and Alessandro Serretti",

year = "2009",

month = mar,

doi = "10.1159/000202826",

language = "English",

volume = "59",

pages = "23--27",

journal = "Neuropsychobiology",

issn = "0302-282X",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits

AU - Giegling, Ina

AU - Moreno-De-Luca, Daniel

AU - Calati, Raffaella

AU - Hartmann, Annette M.

AU - Möller, Hans Jürgen

AU - De Ronchi, Diana

AU - Rujescu, Dan

AU - Serretti, Alessandro

PY - 2009/3

Y1 - 2009/3

N2 - Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.

AB - Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question.

KW - DOPA decarboxylase

KW - Dopaminergic system

KW - Genetics

KW - Personality traits

KW - Tyrosine hydroxylase

UR - http://www.scopus.com/inward/record.url?scp=60049090044&partnerID=8YFLogxK

U2 - 10.1159/000202826

DO - 10.1159/000202826

M3 - Article

C2 - 19221445

AN - SCOPUS:60049090044

SN - 0302-282X

VL - 59

SP - 23

EP - 27

JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 1

ER -

Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits

Abstract

Keywords

Access to Document

Fingerprint

Cite this