Typhoid fever & vaccine development: A partially answered question

Sandhya A. Marathe, Amit Lahiri, Vidya Devi Negi, Dipshikha Chakravortty

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen Salmonella enterica serovar Typhi (S. Typhi). The extra-intestinal infections caused by Salmonella are very fatal. The incidence of typhoid fever remains very high in impoverished areas and the emergence of multidrug resistance has made the situation worse. To combat and to reduce the morbidity and mortality caused by typhoid fever, many preventive measures and strategies have been employed, the most important being vaccination. In recent years, many Salmonella vaccines have been developed including live attenuated as well as DNA vaccines and their clinical trials have shown encouraging results. But with the increasing antibiotic resistance, the development of potent vaccine candidate for typhoid fever is a need of the hour. This review discusses the latest trends in the typhoid vaccine development and the clinical trials which are underway.

Original languageEnglish
Pages (from-to)161-169
Number of pages9
JournalIndian Journal of Medical Research
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • DNA vaccine
  • Immunity
  • Salmonella
  • Typhoid fever
  • Vaccination


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