Type 2 diabetes and cancer

Emily Jane Gallagher; Ruslan Novosyadlyy; Derek LeRoith

doi:10.1002/9781118387658.ch21

Type 2 diabetes and cancer

Emily Jane Gallagher, Ruslan Novosyadlyy, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Epidemiologic studies have convincingly shown a relationship between obesity and type 2 diabetes and an increased risk of developing many types of cancer, as well as in some cases an increased risk of cancer-related mortality. There are a number of possible factors that maybe causally related such as hyperglycemia, hyperinsulinemia, hyperlipidemia, IGFs, adipokines, and inflammatory cytokines. There is currently intense investigation to determine which factors are involved as this may lead to future therapeutic options. This chapter will describe in general, the epidemiologic studies as well as discuss the various animal models used to identify the possible causal mechanisms linking T2D and cancer.

Original language	English
Title of host publication	International Textbook of Diabetes Mellitus
Publisher	wiley
Pages	306-315
Number of pages	10
ISBN (Electronic)	9781118387658
ISBN (Print)	9780470658611
DOIs	https://doi.org/10.1002/9781118387658.ch21
State	Published - 1 Jan 2015

Keywords

cancer
diabetes
epidemiology
mouse models

Access to Document

10.1002/9781118387658.ch21

Cite this

@inbook{b16f7ef4dafb4d929cfbebf2acfbf159,

title = "Type 2 diabetes and cancer",

abstract = "Epidemiologic studies have convincingly shown a relationship between obesity and type 2 diabetes and an increased risk of developing many types of cancer, as well as in some cases an increased risk of cancer-related mortality. There are a number of possible factors that maybe causally related such as hyperglycemia, hyperinsulinemia, hyperlipidemia, IGFs, adipokines, and inflammatory cytokines. There is currently intense investigation to determine which factors are involved as this may lead to future therapeutic options. This chapter will describe in general, the epidemiologic studies as well as discuss the various animal models used to identify the possible causal mechanisms linking T2D and cancer.",

keywords = "cancer, diabetes, epidemiology, mouse models",

author = "Gallagher, {Emily Jane} and Ruslan Novosyadlyy and Derek LeRoith",

note = "Publisher Copyright: {\textcopyright} 2004, 2015 by John Wiley & Sons Ltd.",

year = "2015",

month = jan,

day = "1",

doi = "10.1002/9781118387658.ch21",

language = "English",

isbn = "9780470658611",

pages = "306--315",

booktitle = "International Textbook of Diabetes Mellitus",

publisher = "wiley",

}

TY - CHAP

T1 - Type 2 diabetes and cancer

AU - Gallagher, Emily Jane

AU - Novosyadlyy, Ruslan

AU - LeRoith, Derek

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Epidemiologic studies have convincingly shown a relationship between obesity and type 2 diabetes and an increased risk of developing many types of cancer, as well as in some cases an increased risk of cancer-related mortality. There are a number of possible factors that maybe causally related such as hyperglycemia, hyperinsulinemia, hyperlipidemia, IGFs, adipokines, and inflammatory cytokines. There is currently intense investigation to determine which factors are involved as this may lead to future therapeutic options. This chapter will describe in general, the epidemiologic studies as well as discuss the various animal models used to identify the possible causal mechanisms linking T2D and cancer.

AB - Epidemiologic studies have convincingly shown a relationship between obesity and type 2 diabetes and an increased risk of developing many types of cancer, as well as in some cases an increased risk of cancer-related mortality. There are a number of possible factors that maybe causally related such as hyperglycemia, hyperinsulinemia, hyperlipidemia, IGFs, adipokines, and inflammatory cytokines. There is currently intense investigation to determine which factors are involved as this may lead to future therapeutic options. This chapter will describe in general, the epidemiologic studies as well as discuss the various animal models used to identify the possible causal mechanisms linking T2D and cancer.

KW - cancer

KW - diabetes

KW - epidemiology

KW - mouse models

UR - http://www.scopus.com/inward/record.url?scp=105001456180&partnerID=8YFLogxK

U2 - 10.1002/9781118387658.ch21

DO - 10.1002/9781118387658.ch21

M3 - Chapter

AN - SCOPUS:105001456180

SN - 9780470658611

SP - 306

EP - 315

BT - International Textbook of Diabetes Mellitus

PB - wiley

ER -

Type 2 diabetes and cancer

Abstract

Keywords

Access to Document

Fingerprint

Cite this