Abstract
A common inherited disorder of steroidogenesis in man, 21-hydroxylase (21-OH) deficiency, is linked to the HLA major histocompatibility complex (MHC)1, and is associated in particular with certain allotypes of the HLA-linked complement proteins2,3. Recently, this disorder was demonstrated to result from a defective structural gene for the 21-OH enzyme, also termed cytochrome P-450C21 (ref. 4). The human (HLA) and murine (H-2) MHCs are homologous in overall organization and in the structures of their component genes5. To determine whether 21-OH genes are located in the H-2 complex, we have now used a bovine adrenal complementary DNA clone encoding part of 21-OH6 to examine a cluster of overlapping cosmid clones derived from the S region of the BALB/c mouse7. We found that there are two 21-OH genes in this region, located immediately 3′ to the C4 and Slp genes.
Original language | English |
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Pages (from-to) | 465-467 |
Number of pages | 3 |
Journal | Nature |
Volume | 312 |
Issue number | 5993 |
DOIs | |
State | Published - 1984 |
Externally published | Yes |