Abstract
While the elevations in pain thresholds induced by cold-water swims are reduced in hypophysectomized rats, morphine analgesia is increased. The procedure of restricting rats to 2% saline as their only liquid nourishment for 72 hr reduces pituitary endorphins to 50% of normal values. This procedure was used to ascertain whether analgesia induced by morphine or cold-water swims would be similarly altered. The flinch-jump thresholds of 10 rats were monitored following morphine injections and cold-water swims under normal and 2% saline drinking conditions. Unlike the recently-reported elimination of acupuncture analgesia following this procedure, the 2% saline regimen failed to alter significantly the analgesic responses to morphine and cold-water swims.
Original language | English |
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Pages (from-to) | 805-806 |
Number of pages | 2 |
Journal | Physiology and Behavior |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1980 |
Externally published | Yes |
Keywords
- 2% Saline
- Analgesia
- Cold-water Stress
- Morphine
- Pain
- Pituitary endorphins
- Rats