Two % saline treatment: Failure to alter opiate and cold-water stress analgesia

Richard J. Bodnar, Dennis D. Kelly, Lucy W. Thomas, Murray Glusman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

While the elevations in pain thresholds induced by cold-water swims are reduced in hypophysectomized rats, morphine analgesia is increased. The procedure of restricting rats to 2% saline as their only liquid nourishment for 72 hr reduces pituitary endorphins to 50% of normal values. This procedure was used to ascertain whether analgesia induced by morphine or cold-water swims would be similarly altered. The flinch-jump thresholds of 10 rats were monitored following morphine injections and cold-water swims under normal and 2% saline drinking conditions. Unlike the recently-reported elimination of acupuncture analgesia following this procedure, the 2% saline regimen failed to alter significantly the analgesic responses to morphine and cold-water swims.

Original languageEnglish
Pages (from-to)805-806
Number of pages2
JournalPhysiology and Behavior
Volume24
Issue number4
DOIs
StatePublished - Apr 1980
Externally publishedYes

Keywords

  • 2% Saline
  • Analgesia
  • Cold-water Stress
  • Morphine
  • Pain
  • Pituitary endorphins
  • Rats

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