Two Cases with Features of Lymphocyte Variant Hypereosinophilic Syndrome with STAT3 SH2 Domain Mutations

Sebastian Fernandez-Pol, Bruce Petersen, Jo Ellen Murphy, Jean S. Oak, Erica B.K. Wang, Kerri E. Rieger, Youn H. Kim, Michael S. Khodadoust, Carlos J. Suarez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Lymphocyte variant hypereosinophilic syndrome (LV-HES) is a rare cause of eosinophilia that is due to eosinophilipoietic cytokine production by an immunophenotypically abnormal T-cell clone. The molecular pathogenesis of this disorder is largely unknown and only 1 case of LV-HES with a pathogenic STAT3 mutation has been described thus far. Here we report 2 cases of LV-HES with STAT3 SH2 domain mutations. These cases further support the model that activation of STAT3 signaling through STAT3 SH2 domain mutations is a recurrent event in LV-HES.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalAmerican Journal of Surgical Pathology
Volume45
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • STAT3
  • T-cell lymphoma
  • eosinophilia
  • lymphocyte variant hypereosinophilic syndrome

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