Twenty years of Alzheimer's disease-causing mutations

Alison Goate, John Hardy

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations


In this study, we review our finding of APP mutations in Alzheimer's disease in 1990-1991 with the benefit of 20 years' perspective. We discuss the historical context in which we made the finding, its immediate and continuing effects on research activity and our hopes for successful clinical testing of the hypothesis. We also briefly discuss the effects finding APP mutations has had on our own careers and those of our colleagues from 1991.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalJournal of Neurochemistry
Issue numberSUPPL. 1
StatePublished - Jan 2012
Externally publishedYes


  • APP
  • Alzheimer's disease
  • amyloid
  • genetics
  • tau


Dive into the research topics of 'Twenty years of Alzheimer's disease-causing mutations'. Together they form a unique fingerprint.

Cite this