Tumour bound immunoglobulins. The in vitro fixation of radioiodine labelled antiimmunoglobulin reagents by tumour cells

Radioiodine labelled globulins from antisera directed against mouse immunoglobulin were fixed by cells of various mouse ascites tumors, thus indicating that the cells were coated in vivo with immunoglobulins. The amounts of tumor bound immunoglobulin in the tumor bearing animal increased as the time interval between tumor inoculation and the harvest of tumor cells increased. Tumor cells from mice which had been irradiated prior to the tumor inoculation were associated, in general, with lower amounts of immunoglobulin than tumor cells from unirradiated mice.