TY - JOUR
T1 - Tubular Pyloric Gland Adenoma of the Left and Right Hepatic Ducts
AU - Hatzibougias, Dimitris I.
AU - Fouzas, Ioannis
AU - Bobos, Mattheos
AU - Papanikolaou, Vasileios
AU - Daoudaki, Maria
AU - Kotoula, Vasiliki
AU - Hytiroglou, Prodromos
AU - Albores-Saavedra, Jorge
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2015/6
Y1 - 2015/6
N2 - Pyloric gland adenomas (PGAs) of the extrahepatic biliary system are rare lesions. We report a case of a tubular PGA that led to biliary obstruction. The tumor was located at the confluence of the right and left hepatic ducts, extending to the left hepatic duct. The tumor cells expressed MUC6 and MUC5AC. MUC1 and CD10 were focally positive. MUC2, p53, and CDX2 were not expressed. The Ki67 positivity was estimated at <15%. None of the KRAS, NRAS, BRAF, EGFR coding regions resulted in clinically relevant amino acid substitutions. SNP rs1050171 (EGFR p.Q787Q, silent mutation) corresponding to c.2361G>A transition in exon 20 was noticed. Awareness of this rare lesion is important for pathologists and clinicians alike, because it may cause significant morphologic and clinical difficulties, especially when presenting as an obstructive mass. Because of the possible risk of evolving malignancy, surgical resection is recommended whenever possible.
AB - Pyloric gland adenomas (PGAs) of the extrahepatic biliary system are rare lesions. We report a case of a tubular PGA that led to biliary obstruction. The tumor was located at the confluence of the right and left hepatic ducts, extending to the left hepatic duct. The tumor cells expressed MUC6 and MUC5AC. MUC1 and CD10 were focally positive. MUC2, p53, and CDX2 were not expressed. The Ki67 positivity was estimated at <15%. None of the KRAS, NRAS, BRAF, EGFR coding regions resulted in clinically relevant amino acid substitutions. SNP rs1050171 (EGFR p.Q787Q, silent mutation) corresponding to c.2361G>A transition in exon 20 was noticed. Awareness of this rare lesion is important for pathologists and clinicians alike, because it may cause significant morphologic and clinical difficulties, especially when presenting as an obstructive mass. Because of the possible risk of evolving malignancy, surgical resection is recommended whenever possible.
KW - KRAS
KW - extrahepatic biliary system
KW - hepatic ducts
KW - pyloric gland adenoma
KW - sequence
UR - http://www.scopus.com/inward/record.url?scp=84966616976&partnerID=8YFLogxK
U2 - 10.1177/1066896915625110
DO - 10.1177/1066896915625110
M3 - Article
C2 - 26762143
AN - SCOPUS:84966616976
SN - 1066-8969
VL - 24
SP - 347
EP - 352
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 4
ER -