Tuberculosis induced changes to the osseous cranial base and its potential effect on hearing

Armand L. Balboni; Andrew D. Bergemann; Joy S. Reidenberg; Jeffrey T. Laitman

doi:10.1002/ar.20675

Tuberculosis induced changes to the osseous cranial base and its potential effect on hearing

Armand L. Balboni, Andrew D. Bergemann, Joy S. Reidenberg, Jeffrey T. Laitman

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2 Scopus citations

Abstract

Our prior work suggested that petro-occipital fissure (POF) ossification may be altered in clinicopathologies of the cranial base such as hearing loss (Balboni et al., 2005). Here we demonstrate an accelerated and statistically significant ossification of the POF and cochlear aqueduct (CA) in a historical population of patients diagnosed with tuberculosis (TB). While a number of studies have sought to reduce the importance of the POF/CA to hearing, given its anatomical location, evolutionary conservation across mammals and the mounting data linking morphological changes of the POF/CA to the temporal onset of hearing loss and tinnitus, it is becoming difficult to maintain that its function is not related to inner ear homeostasis.

Original language	English
Pages (from-to)	488-490
Number of pages	3
Journal	Anatomical Record
Volume	291
Issue number	5
DOIs	https://doi.org/10.1002/ar.20675
State	Published - May 2008

Keywords

Cochlear aqueduct
Disseminated tuberculosis
Hearing loss
Petro-occipital fissure
Tinnitus
Vestibular dysfunction

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abstract = "Our prior work suggested that petro-occipital fissure (POF) ossification may be altered in clinicopathologies of the cranial base such as hearing loss (Balboni et al., 2005). Here we demonstrate an accelerated and statistically significant ossification of the POF and cochlear aqueduct (CA) in a historical population of patients diagnosed with tuberculosis (TB). While a number of studies have sought to reduce the importance of the POF/CA to hearing, given its anatomical location, evolutionary conservation across mammals and the mounting data linking morphological changes of the POF/CA to the temporal onset of hearing loss and tinnitus, it is becoming difficult to maintain that its function is not related to inner ear homeostasis.",

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AU - Balboni, Armand L.

AU - Bergemann, Andrew D.

AU - Reidenberg, Joy S.

AU - Laitman, Jeffrey T.

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AB - Our prior work suggested that petro-occipital fissure (POF) ossification may be altered in clinicopathologies of the cranial base such as hearing loss (Balboni et al., 2005). Here we demonstrate an accelerated and statistically significant ossification of the POF and cochlear aqueduct (CA) in a historical population of patients diagnosed with tuberculosis (TB). While a number of studies have sought to reduce the importance of the POF/CA to hearing, given its anatomical location, evolutionary conservation across mammals and the mounting data linking morphological changes of the POF/CA to the temporal onset of hearing loss and tinnitus, it is becoming difficult to maintain that its function is not related to inner ear homeostasis.

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KW - Tinnitus

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Tuberculosis induced changes to the osseous cranial base and its potential effect on hearing

Abstract

Keywords

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