TY - JOUR
T1 - Trypanosoma cruzi-associated cerebrovascular disease
T2 - A case-control study in Eastern Colombia
AU - Leon-Sarmiento, Fidias E.
AU - Mendoza, Eder
AU - Torres-Hillera, Martin
AU - Pinto, Neyla
AU - Prada A, Janette
AU - Silva, Clara A.
AU - Vera C, Silvia J.
AU - Castillo, Erwin
AU - Valderrama, Vladimir
AU - Prada, Didier G.
AU - Bayona-Prieto, Jaime
AU - Garcia, Ingrid
PY - 2004/1/15
Y1 - 2004/1/15
N2 - Trypanosoma cruzi infection is a common cause of cardiopathy in South America leading it eventually to an established stroke; however, the association between T. cruzi infection itself and cerebrovascular disease is still unknown. We did a case-control study at Eastern Colombia and found that T. cruzi infection was more frequent and statistically significant in stroke cases (24.4%) than controls (1.9%), (Chi square: 21.72; OR: 16.13; 95% confidence interval (CI): 3.64-71.4; p<0.00001). After removing the seropositive patients with cardiological abnormalities, the significance still remained by multivariate analysis (p<0.05). This is the first case-control study that demonstrated a significant link between this infection and symptomatic cerebrovascular disease, mainly ischemic, regardless of cardiac abnormalities. Therefore, we recommend that patients with stroke must be screened for T. cruzi infection if they currently live or have lived in places where this parasite is considered endemic.
AB - Trypanosoma cruzi infection is a common cause of cardiopathy in South America leading it eventually to an established stroke; however, the association between T. cruzi infection itself and cerebrovascular disease is still unknown. We did a case-control study at Eastern Colombia and found that T. cruzi infection was more frequent and statistically significant in stroke cases (24.4%) than controls (1.9%), (Chi square: 21.72; OR: 16.13; 95% confidence interval (CI): 3.64-71.4; p<0.00001). After removing the seropositive patients with cardiological abnormalities, the significance still remained by multivariate analysis (p<0.05). This is the first case-control study that demonstrated a significant link between this infection and symptomatic cerebrovascular disease, mainly ischemic, regardless of cardiac abnormalities. Therefore, we recommend that patients with stroke must be screened for T. cruzi infection if they currently live or have lived in places where this parasite is considered endemic.
KW - Case-control studies
KW - Cerebrovascular disease
KW - Colombia
KW - Neuroepidemiology
KW - Neurotrypanosomiasis
KW - Trypanosoma cruzi
UR - https://www.scopus.com/pages/publications/10744224103
U2 - 10.1016/j.jns.2003.08.015
DO - 10.1016/j.jns.2003.08.015
M3 - Article
C2 - 14675611
AN - SCOPUS:10744224103
SN - 0022-510X
VL - 217
SP - 61
EP - 64
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -