Trypanosoma cruzi-associated cerebrovascular disease: A case-control study in Eastern Colombia

Fidias E. Leon-Sarmiento, Eder Mendoza, Martin Torres-Hillera, Neyla Pinto, Janette Prada A, Clara A. Silva, Silvia J. Vera C, Erwin Castillo, Vladimir Valderrama, Didier G. Prada, Jaime Bayona-Prieto, Ingrid Garcia

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39 Scopus citations


Trypanosoma cruzi infection is a common cause of cardiopathy in South America leading it eventually to an established stroke; however, the association between T. cruzi infection itself and cerebrovascular disease is still unknown. We did a case-control study at Eastern Colombia and found that T. cruzi infection was more frequent and statistically significant in stroke cases (24.4%) than controls (1.9%), (Chi square: 21.72; OR: 16.13; 95% confidence interval (CI): 3.64-71.4; p<0.00001). After removing the seropositive patients with cardiological abnormalities, the significance still remained by multivariate analysis (p<0.05). This is the first case-control study that demonstrated a significant link between this infection and symptomatic cerebrovascular disease, mainly ischemic, regardless of cardiac abnormalities. Therefore, we recommend that patients with stroke must be screened for T. cruzi infection if they currently live or have lived in places where this parasite is considered endemic.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalJournal of the Neurological Sciences
Issue number1
StatePublished - 15 Jan 2004
Externally publishedYes


  • Case-control studies
  • Cerebrovascular disease
  • Colombia
  • Neuroepidemiology
  • Neurotrypanosomiasis
  • Trypanosoma cruzi


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