@article{6e3fd10eb927481e8a3dbe71eda5557d,
title = "TRIM25 in the regulation of the antiviral innate immunity",
abstract = "TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5-mitochondrial antiviral signaling protein-TRAF6 antiviral axis and modulation of p53 levels and activity. In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates intracellular signaling and/or RNA virus replication.",
keywords = "E3 ubiquitin ligase, Innate immunity, TRIM25, Ubiquitination, Virus",
author = "Mar{\'i}a Mart{\'i}n-Vicente and Medrano, {Luz M.} and Salvador Resino and Adolfo Garc{\'i}a-Sastre and Isidoro Mart{\'i}nez",
note = "Funding Information: We gratefully acknowledge financial support from Instituto de Salud Carlos III, grant numbers PI15CIII/00024 (IM), PI14CIII/00011 (SR), and CD14/00002 (LM). AG-S laboratories are partly supported by NIH grants R33AI119304, R21AI129486, U19AI106754, P01AI097092, R01DA033773, R01AI088770, U19AI117873, U19AI118610, R01AI125524, U01AI124297, and R01AI127658, contract HHSN272201300023C and by CRIP (Center for Research on Influenza Pathogenesis), an NIAID funded Center of Excellence for Influenza Surveillance and Research (CEIRS, contract HHSN272201400008C). Publisher Copyright: {\textcopyright} 2017 Mart{\'i}n-Vicente, Medrano, Resino, Garc{\'i}a-Sastre and Mart{\'i}nez.",
year = "2017",
month = sep,
day = "22",
doi = "10.3389/fimmu.2017.01187",
language = "English",
volume = "8",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Media S.A.",
number = "SEP",
}