Triggering the interferon antiviral response through an IKK-related pathway

Sonia Sharma; Benjamin R. TenOever; Nathalie Grandvaux; Guo Ping Zhou; Rongtuan Lin; John Hiscott

doi:10.1126/science.1081315

Triggering the interferon antiviral response through an IKK-related pathway

Sonia Sharma
, Benjamin R. TenOever
, Nathalie Grandvaux
, Guo Ping Zhou
, Rongtuan Lin
, John Hiscott

Research output: Contribution to journal › Article › peer-review

1489 Scopus citations

Abstract

Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)-related kinases IKKε and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.

Original language	English
Pages (from-to)	1148-1151
Number of pages	4
Journal	Science
Volume	300
Issue number	5622
DOIs	https://doi.org/10.1126/science.1081315
State	Published - 16 May 2003
Externally published	Yes

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title = "Triggering the interferon antiviral response through an IKK-related pathway",

abstract = "Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)-related kinases IKKε and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.",

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T1 - Triggering the interferon antiviral response through an IKK-related pathway

AU - Sharma, Sonia

AU - TenOever, Benjamin R.

AU - Grandvaux, Nathalie

AU - Zhou, Guo Ping

AU - Lin, Rongtuan

AU - Hiscott, John

PY - 2003/5/16

Y1 - 2003/5/16

N2 - Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)-related kinases IKKε and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.

AB - Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires cooperative activation of numerous transcription factors. Although signaling pathways that activate the transcription factors nuclear factor κB and ATF-2/c-Jun have been well characterized, activation of the interferon regulatory factors IRF-3 and IRF-7 has remained a critical missing link in understanding interferon signaling. We report here that the IκB kinase (IKK)-related kinases IKKε and TANK-binding kinase 1 are components of the virus-activated kinase that phosphorylate IRF-3 and IRF-7. These studies illustrate an essential role for an IKK-related kinase pathway in triggering the host antiviral response to viral infection.

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VL - 300

SP - 1148

EP - 1151

JO - Science

JF - Science

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ER -

Triggering the interferon antiviral response through an IKK-related pathway

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