Trends in MitraClip, mitral valve repair, and mitral valve replacement from 2000 to 2016

Selena Zhou, Natalia Egorova, Gil Moskowitz, Gennaro Giustino, Gorav Ailawadi, Michael A. Acker, Marc Gillinov, Alan Moskowitz, Annetine Gelijns

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective: The dissemination of mitral valve repair as the first-line treatment and the introduction of MitraClip for patients who have a prohibitive risk for surgery have changed the landscape of mitral valve intervention. The aim of this study is to provide current and generalizable data regarding the trend of mitral valve interventions and outcomes from 2000 to 2016. Methods: Patients ≥18 years of age who underwent mitral-valve interventions were identified using the National Inpatient Sample database. National estimates were generated by means of discharge weights; comorbid conditions were identified using Elixhauser methods. All trends were analyzed with JoinPoint software. Results: A total of 656,030 mitral valve interventions (298,102 mitral valve replacement, 349,053 mitral valve repair, and 8875 MitraClip) were assessed. No changes in rate of procedures (per 100,000 people in the United States) were observed over this period (annual percent change, −0.4; 95% confidence limit, −1.1 to 0.3; P = .3). From 2000 to 2010, the number of replacements decreased by 5.6% per year (P < .001), whereas repair increased by 8.4% per year from 2000 to 2006 (P < .001). MitraClip procedures increased by 84.4% annually from 2013 to 2016 (P < .001). The burden of comorbidities increased throughout the study for all groups, with the greatest score for MitraClip recipients. Overall, length of stay has decreased for all interventions, most significantly for MitraClip. In-hospital mortality decreased from 8.5% to 3.7% for all interventions, with MitraClip having the most substantial decrease from 3.6% to 1.5%. Conclusions: Over a 17-year period, mitral-valve interventions were associated with improved outcomes despite being applied to an increasingly sicker population.

Original languageEnglish
Pages (from-to)551-562.e4
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number2
StatePublished - Aug 2021


  • MitraClip
  • in-hospital mortality
  • length of stay
  • mitral valve repair
  • mitral valve replacement
  • surgical trends


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