Trends in length of stay for Neonatal Intensive Care Unit patients who die before hospital discharge

Katherine F. Guttmann, Nicholas Puoplo, Felix Richter, Andrea S. Weintraub

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective: The objectives of this study were to establish days between birth and death for neonates over a 14-year period, determine if days between birth and death have changed over time across gestational age cohorts, and identify diagnoses which may put infants at high risk of prolonged hospitalization leading to death. Study Design: This was a single-site, retrospective chart review of inborn infants who died prior to hospital discharge. Results: Two hundred and thirty-nine patients born between 1/1/2006 and 12/31/2020 met inclusion criteria. Days until death ranged from 0 to 300 with a median of 6 days (interquartile range = 23). Median days until death increased over time, with a statistically significant increase between epoch 1 and epoch 2 (p = 0.016) but not between epoch 2 and epoch 3 (p = 0.618). Extremely premature infants died earlier than more mature infants (p < 0.001). In addition, infants with complex congenital heart disease or a gastrointestinal (GI) catastrophe died later (p < 0.001 and p < 0.001, respectively) than newborns without cardiac or GI issues. Conclusion: Our findings demonstrate an increase in time to death for newborns who did not survive to hospital discharge over a 14-year period. This trend suggests that the dynamics informing Meadows' assertion that doomed infants die early may be shifting, with some seriously ill infants who die before hospital discharge surviving longer than previously described. More research is needed to understand how best to care for babies who will not survive to discharge and to explore when supports such as palliative care consultation may be beneficial.

Original languageEnglish
Pages (from-to)700-705
Number of pages6
JournalAmerican Journal of Perinatology
Issue number6
StatePublished - 7 Jul 2021


  • death
  • ethics
  • neonate
  • palliative care


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