Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

Naomi N. Hunder; Herschel Wallen; Jianhong Cao; Deborah W. Hendricks; John Z. Reilly; Rebecca Rodmyre; Achim Jungbluth; Sacha Gnjatic; John A. Thompson; Cassian Yee

doi:10.1056/NEJMoa0800251

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

Naomi N. Hunder
, Herschel Wallen
, Jianhong Cao
, Deborah W. Hendricks
, John Z. Reilly
, Rebecca Rodmyre
, Achim Jungbluth
, Sacha Gnjatic
, John A. Thompson
, Cassian Yee

Research output: Contribution to journal › Article › peer-review

806 Scopus citations

Abstract

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

Original language	English
Pages (from-to)	2698-2703
Number of pages	6
Journal	New England Journal of Medicine
Volume	358
Issue number	25
DOIs	https://doi.org/10.1056/NEJMoa0800251
State	Published - 19 Jun 2008
Externally published	Yes

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10.1056/NEJMoa0800251

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title = "Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1",

abstract = "We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.",

author = "Hunder, \{Naomi N.\} and Herschel Wallen and Jianhong Cao and Hendricks, \{Deborah W.\} and Reilly, \{John Z.\} and Rebecca Rodmyre and Achim Jungbluth and Sacha Gnjatic and Thompson, \{John A.\} and Cassian Yee",

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T1 - Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

AU - Hunder, Naomi N.

AU - Wallen, Herschel

AU - Cao, Jianhong

AU - Hendricks, Deborah W.

AU - Reilly, John Z.

AU - Rodmyre, Rebecca

AU - Jungbluth, Achim

AU - Gnjatic, Sacha

AU - Thompson, John A.

AU - Yee, Cassian

PY - 2008/6/19

Y1 - 2008/6/19

N2 - We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

AB - We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

UR - https://www.scopus.com/pages/publications/45549099784

U2 - 10.1056/NEJMoa0800251

DO - 10.1056/NEJMoa0800251

M3 - Article

C2 - 18565862

AN - SCOPUS:45549099784

SN - 0028-4793

VL - 358

SP - 2698

EP - 2703

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 25

ER -

Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

Abstract

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