Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine

Joel R. Rosh, Hope B. Tang, Lloyd Mayer, Gabriel Groisman, Sheeja K. Abraham, Alice Prince

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Gastrointestinal manifestations of chronic granulomatous disease of childhood include granulomatous inflammatory bowel disease. Severe colitis and perirectal disease developed in a 12-year-old boy with chronic granulomatous disease while he was receiving interferon gamma therapy. The boy had a deficiency of the 22 kd light chain of the cytochrome b heterodimer. After conventional medical therapy proved to be ineffective, a rapid clinical response was obtained to cyclosporine. (J PEDIATR 1995;126:143-5).

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalJournal of Pediatrics
Volume126
Issue number1
DOIs
StatePublished - Jan 1995

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