Treatment of in-stent restenosis.

G. S. Mintz, R. Mehran, R. Waksman, A. D. Pichard, K. M. Kent, L. F. Satler, M. B. Leon

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


Although in-stent restenosis is the result of neointimal hyperplasia, mechanical problems (e.g. stent underexpansion) that occurred during implantation may result in restenosis at follow-up. The treatment of in-stent restenosis, begins with identification of these occult mechanical problems. Thereafter, in-stent restenosis can be treated with PTCA, atheroablation, or additional stent implantation; it is nuclear which technique is superior. Not all in-stent restenosis lesions have a similar risk of recurrence. Recurrence appears to depend on several markers of biologic activity: focal vs diffuse in-stent restenosis, the first episode vs recurrent in-stent restenosis, and early vs late recurrence. Vascular brachytherapy has emerged as the most promising way to treat high-risk lesion subsets.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalSeminars in interventional cardiology : SIIC
Issue number2
StatePublished - Jun 1998
Externally publishedYes


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