TY - JOUR
T1 - Treatment of food anaphylaxis with traditional Chinese herbal remedies
T2 - From mouse model to human clinical trials
AU - Wang, Julie
PY - 2013/8
Y1 - 2013/8
N2 - PURPOSE OF REVIEW: To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine. RECENT FINDINGS: FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges. SUMMARY: FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.
AB - PURPOSE OF REVIEW: To describe the development of a novel treatment for food allergy, named the food allergy herbal formula-2 (FAHF-2), that is based on traditional Chinese medicine. RECENT FINDINGS: FAHF-2 has proven to be well tolerated and effective for the treatment of food allergies in murine models of peanut and multiple food allergies. These results are accompanied by evidence of favorable immune modulation, and the effects are persistent after the discontinuation of treatment. Early clinical trials demonstrate the safety and tolerability of this formula in individuals with food allergies. An ongoing Phase II clinical trial will evaluate the efficacy of FAHF-2 in protecting individuals from allergen-induced allergic reactions during oral food challenges. SUMMARY: FAHF-2 is an herbal formula that has a high safety profile and has shown to prevent anaphylaxis in murine models of food allergy. Similar findings in clinical trials could bring a novel treatment for food allergies.
KW - Anaphylaxis
KW - Food allergy
KW - Herbs
KW - Traditional Chinese medicine
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=84880126303&partnerID=8YFLogxK
U2 - 10.1097/ACI.0b013e3283615bc4
DO - 10.1097/ACI.0b013e3283615bc4
M3 - Review article
C2 - 23799334
AN - SCOPUS:84880126303
SN - 1528-4050
VL - 13
SP - 386
EP - 391
JO - Current Opinion in Allergy and Clinical Immunology
JF - Current Opinion in Allergy and Clinical Immunology
IS - 4
ER -