Treatment of diversion colitis by short-chain fatty acids - Prospective and double-blind study

Fran Çois Guillemot, Jean Frédéric Colombel, Christelle Neut, Nathalie Verplanck, Martine Lecomte, Claude Romond, Jean Claude Paris, Antoine Cortot

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Diminished production of short-chain fatty acids (SCFA) by altered flora has been suggested in the pathogenesis of diversion colitis (DC). We evaluated prospectively the effectiveness of SCFA irrigation in 13 patients with excluded colon (eight males, five females; mean age, 48 years). The causes of diversion were inflammatory bowel disease (n=4), colonic cancer (n=2), sigmoid diverticulitis with perforation (n=3), ischiorectal abscess (n=2), and miscellaneous (n=2). Patients were given, twice a day for 14 days in a double-blind manner, a 60-ml enema containing either SCFA (acetate: 60 mmol/liter; proprionate: 30 mmol/liter; and N-butyrate: 40 mmol/ liter) (Group 1; n=7) or isotonic NaCl (Group 2; n=6). Endoscopy with biopsies was performed before starting the trial (D1) and 14 days later (D14). On D1 all patients had endoscopic and histologic findings suggestive of DC. No endoscopic or histologic changes were observed on D14 in either group. We conclude that endoscopic and histologic lesions of DC were not improved by SCFA irrigation during the 14 days.

Original languageEnglish
Pages (from-to)861-864
Number of pages4
JournalDiseases of the Colon and Rectum
Issue number10
StatePublished - Oct 1991
Externally publishedYes


  • Diversion colitis
  • Short-chain fatty acids


Dive into the research topics of 'Treatment of diversion colitis by short-chain fatty acids - Prospective and double-blind study'. Together they form a unique fingerprint.

Cite this