Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U))

Orellana Juan; Steven A. Teich; Jacqueline S. Winterkorn; Usha Mathur-Wagh; Sandra Handwerger; Haran Schlamm; Stephen C. Malamud; Stanley R. Yancovitz; Donna M. Cederberg; Donna S. Mildvan

doi:10.1136/bjo.72.7.525

Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U))

Orellana Juan, Steven A. Teich, Jacqueline S. Winterkorn, Usha Mathur-Wagh, Sandra Handwerger, Haran Schlamm, Stephen C. Malamud, Stanley R. Yancovitz, Donna M. Cederberg, Donna S. Mildvan

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9 Scopus citations

Abstract

Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.

Original language	English
Pages (from-to)	525-529
Number of pages	5
Journal	British Journal of Ophthalmology
Volume	72
Issue number	7
DOIs	https://doi.org/10.1136/bjo.72.7.525
State	Published - 1988
Externally published	Yes

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Juan, O., Teich, S. A., Winterkorn, J. S., Mathur-Wagh, U., Handwerger, S., Schlamm, H., Malamud, S. C., Yancovitz, S. R., Cederberg, D. M., & Mildvan, D. S. (1988). Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U)). British Journal of Ophthalmology, 72(7), 525-529. https://doi.org/10.1136/bjo.72.7.525

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title = "Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U))",

abstract = "Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.",

author = "Orellana Juan and Teich, {Steven A.} and Winterkorn, {Jacqueline S.} and Usha Mathur-Wagh and Sandra Handwerger and Haran Schlamm and Malamud, {Stephen C.} and Yancovitz, {Stanley R.} and Cederberg, {Donna M.} and Mildvan, {Donna S.}",

year = "1988",

doi = "10.1136/bjo.72.7.525",

language = "English",

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pages = "525--529",

journal = "British Journal of Ophthalmology",

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T1 - Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U))

AU - Juan, Orellana

AU - Teich, Steven A.

AU - Winterkorn, Jacqueline S.

AU - Mathur-Wagh, Usha

AU - Handwerger, Sandra

AU - Schlamm, Haran

AU - Malamud, Stephen C.

AU - Yancovitz, Stanley R.

AU - Cederberg, Donna M.

AU - Mildvan, Donna S.

PY - 1988

Y1 - 1988

N2 - Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.

AB - Six patients (11 eyes) with virologically confirmed cytomegalovirus (CMV) retinitis involving the posterior pole of the eye were treated with a new drug, ganciclovir. Treatment with intravenous ganciclovir consistently halted progression of retinitis and produced improvement in measures of visual function. However, within three weeks after cessation of therapy renewed CMV activity and worsening of visual function were observed in most cases. Maintenance therapy with ganciclovir extended the period of remission from CMV retinitis.

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JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

IS - 7

ER -

Treatment of cytomegalovirus retinitis with ganciclovir (9-[2-hydroxy-1-(hydroxy methy1) ethoxymethyl] guanine (BW B759U))

Abstract

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