@article{ab59d878aa6e4bbeaf17f138cb989857,
title = "Treatment of chemotherapy-resistant advanced ovarian cancer with a combination of cyclophosphamide, hexamethylmelamine, adriamycin, and cis-diamminedichloroplatinum (CHAP)",
abstract = "A four-drug regimen consisting of cyclophosphamide, hexamethylmelamine, adriamycin, and cis-diamminedichloroplatinum (II) (CHAP) produced three complete clinical and seven partial responses for 21 patients with adenocarcinoma of the ovary after objective progression of disease during treatment with standard chemotherapy. Median survival was 15 months for responders and 7 months for all patients.",
author = "Bruckner, {H. W.} and Cohen, {C. J.} and G. Deppe and B. Kabakow and R. Wallach and L. Ratner and Holland, {James F.}",
note = "Funding Information: I Supported in part by Contract l-CM-43703 (Division of Cancer Treatment) and Public Health Service Grant Ca 15936 from the National Cancer Institute, National Institutes of Health. {\textquoteright} To whom reprint requests should be addressed.",
year = "1981",
month = oct,
doi = "10.1016/0090-8258(81)90144-X",
language = "English",
volume = "12",
pages = "150--153",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",
}