Treatment of benign tracheal stenosis using endoluminal spray cryotherapy

Faiz Y. Bhora, Adil Ayub, Craig M. Forleiter, Chyun Yin Huang, Khalid Alshehri, Sadiq Rehmani, Adnan M. Al-Ayoubi, Wissam Raad, Robert S. Lebovics

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Importance Tracheal stenosis is a debilitating disorder with heterogeneity in terms of disease characteristics and management. Repeated recurrences substantially alter patients' quality of life. There is limited evidence for the use of spray cryotherapy (SCT) in the management of benign airway disease. OBJECTIVE To report our early results for the use of SCT in patients with benign tracheal stenosis. DESIGN, SETTING, AND PARTICIPANTS Data were extracted from the medical records of a consecutive series of patients with benign airway stenosis secondary to granulomatosis with polyangiitis (GPA) (n = 13), prior tracheotomy or tracheal intubation (n = 8), and idiopathic strictures (n = 5) treated from September 1, 2013, to September 30, 2015, at a tertiary care hospital. MAIN OUTCOMES AND MEASURES Airway narrowing was quantified on a standard quartile grading scale. Response to treatment was assessed by improvement in airway caliber and the time interval for reintervention. EXPOSURES Delivery of 4 5-second SCT cycles and 2 balloon dilatations. RESULTS Twenty-six patients (median [range] age, 53 [16-83] years; 20 [77%] female) underwent 48 SCT sessions. Spray cryotherapy was successfully used without any substantial intraoperative or postoperative complications in all patients. In a median (range) follow-up of 11 (1-26) months, all patients had improvement in symptoms. Before the institution of SCT, 23 patients (88%) had grade III or IV stenosis. At the last evaluation after induction of SCT, 4 (15%) had grade III or IV stenosis, with a mean (SD) change of 1.39 (0.51) (P <.001). Patients with GPA required significantly fewer SCT procedures (mean [SD], 1.38 [0.96] vs 2.31 [1.18]; P =.03) during the study period. CONCLUSIONS AND RELEVANCE Spray cryotherapy was a safe adjunct modality to accomplish airway patency in patients with benign tracheal stenosis. Although efficacy evidence is limited for SCT, it may be useful for patients who have experienced treatment failure with conventional modalities. Further analysis of this cohort will determine the physiologic durability of the reported short-term changes. Additional trials are warranted for further evaluation of this modality.

Original languageEnglish
Pages (from-to)1082-1087
Number of pages6
JournalJAMA Otolaryngology - Head and Neck Surgery
Volume142
Issue number11
DOIs
StatePublished - 1 Nov 2016
Externally publishedYes

Fingerprint

Dive into the research topics of 'Treatment of benign tracheal stenosis using endoluminal spray cryotherapy'. Together they form a unique fingerprint.

Cite this