Treatment of anemia in patients with chronic heart failure

Stuart D. Katz, Donna Mancini, Ana Silvia Androne, Katarzyna Hryniewicz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Anemia occurs frequently in chronic heart failure (CHF) patients and is associated with increased morbidity and mortality risk. Clinical trials with recombinant human erythropoietin in patients with chronic kidney disease and concomitant structural heart disease have demonstrated beneficial effects on ventricular remodeling but variable effects on clinical outcome. Preliminary clinical trials in patients with CHF demonstrate that erythropoietin therapy is well-tolerated and associated with short-term clinical benefits. The optimum target hemoglobin, erythropoietin dosing regimen, and role of iron supplementation in patients with CHF are not known. Darbepoetin alfa is a glycosylated derivative of erythropoietin with a prolonged half-life that may allow less frequent dosing in CHF populations. Additional studies are needed to determine the safety and efficacy of long-term erythropoietic therapy in CHF patients.

Original languageEnglish
Pages (from-to)S13-S16
JournalJournal of Cardiac Failure
Volume10
Issue number1 SUPPL.
DOIs
StatePublished - Feb 2004
Externally publishedYes

Keywords

  • Erythropoietin
  • blood volume
  • exercise
  • heart failure
  • vascular resistance

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