Treating crescentic glomerulonephritis by targeting macrophages

Anqun Chen, Kyung Lee, John Cijiang He

Research output: Contribution to journalComment/debate

2 Scopus citations

Abstract

Macrophage accumulation in the kidney is associated with the progression of crescentic glomerulonephritis (GN) and is mostly derived from circulating monocytes. FROUNT, a C-C motif chemokine receptor 2 (CCR2)–interacted protein, which is strongly expressed in monocytes/macrophages, enhances macrophage infiltration through CCR2-mediated chemotaxis. In this issue of the journal, Toda et al. reported that disulfiram, an inhibitor of FROUNT, attenuates GN by inhibition of the FROUNT-CCR2 interaction and macrophage migration and activation, suggesting a potential therapeutic role for crescentic GN.

Original languageEnglish
Pages (from-to)1212-1214
Number of pages3
JournalKidney International
Volume102
Issue number6
DOIs
StatePublished - Dec 2022

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