Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

André B. Veras, Moses V. Chao, Mara Getz, Raymond Goetz, Elie Cheniaux, Fabiana L. Lopes, Antonio E. Nardi, Julie Walsh-Messinger, Dolores Malaspina, Thorsten M. Kranz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The association of early trauma exposure with current cognition was examined in a research series of 56 schizophrenia cases with respect to the BDNF Val66Met polymorphism (rs6265, Val66Val, Val66Met, Met66Met), as met allele carriers have reduced neurotrophic activity. The Perceptual Organization Index had a significant negative correlation with trauma exposures only in met carriers, including early physical abuse, general trauma after age 18 years, and physical abuse. Within the Val66Val subgroup, there were no significant correlations between WAIS indices and traumatic experiences.

Original languageEnglish
Pages (from-to)111-113
Number of pages3
JournalPsychiatry Research
Volume271
DOIs
StatePublished - Jan 2019

Keywords

  • BDNF
  • Schizophrenia
  • Trauma

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