Transthyretin-related proteins function to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction

Youra Lee, Hee Lee Do, Won Kho Chang, Young Lee Ah, Mi Jang, Sayeon Cho, Hwan Lee Choong, Suk Lee Jong, Keun Myung Pyung, Byoung Chul Park, Sung Goo Park

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

Purine catabolic pathway in Bacillus subtilis is consisted of more than 14 genes. Among these genes, pucL and pucM are required for uricase activity. While PucL is known to encode the uricase itself, the function of PucM is still unclear although this protein is also indispensable for uric acid decomposition. Here, we provide evidence that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Based on these results, we propose that transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as a hydroxyisourate hydrolase.

Original languageEnglish
Pages (from-to)4769-4774
Number of pages6
JournalFEBS Letters
Volume579
Issue number21
DOIs
StatePublished - 29 Aug 2005
Externally publishedYes

Keywords

  • Hydroxyisourate
  • PucM
  • Transthyretin-related proteins
  • Uric acid
  • Uricase

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