Transplacental transmission of Cryptococcus neoformans to an HIV-exposed premature neonate

M. Patel, K. P. Beckerman, S. Reznik, R. P. Madan, D. L. Goldman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Cryptococcosis during pregnancy is well documented, but transmission of infection to the fetus is rare. We describe a premature neonate born to a mother with congenitally acquired human immunodeficiency virus (HIV) and active cryptococcosis. Histological examination of the placenta revealed Cryptococcus neoformans within the maternal intervillous space with focal invasion into the chorionic villi. A positive serum cryptococcal antigen (1:2) was detected on days 1 and 5 of life. The neonate had no evidence of central nervous system disease and was treated with fluconazole with resolution of antigenemia. This case highlights both the potential for transplacental transmission of C. neoformans infection and the complexities of caring for pregnant mothers who themselves are congenitally infected with HIV.

Original languageEnglish
Pages (from-to)235-237
Number of pages3
JournalJournal of Perinatology
Issue number3
StatePublished - Mar 2012
Externally publishedYes


  • congenital HIV
  • cryptococcus
  • neonate
  • placenta
  • pregnancy


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