TY - JOUR
T1 - Transmission probabilities and durations of immunity for three pathogenic group B Streptococcus serotypes
AU - Percha, Bethany
AU - Newman, M. E.J.
AU - Foxman, Betsy
PY - 2011/8
Y1 - 2011/8
N2 - Group B Streptococcus (GBS) remains a major cause of neonatal sepsis and is an emerging cause of invasive bacterial infections. The 9 known serotypes vary in virulence, and there is little cross-immunity. Key parameters for planning an effective vaccination strategy, such as average length of immunity and transmission probabilities by serotype, are unknown. We simulated GBS spread in a population using a computational model with parameters derived from studies of GBS sexual transmission in a college dormitory. Here we provide estimates of the duration of immunity relative to the transmission probabilities for the 3 GBS serotypes most associated with invasive disease: Ia, III, and V. We also place upper limits on the durations of immunity for serotype Ia (570 days), III (1125 days) and V (260 days). Better transmission estimates are required to establish the epidemiological parameters of GBS infection and determine the best vaccination strategies to prevent GBS disease.
AB - Group B Streptococcus (GBS) remains a major cause of neonatal sepsis and is an emerging cause of invasive bacterial infections. The 9 known serotypes vary in virulence, and there is little cross-immunity. Key parameters for planning an effective vaccination strategy, such as average length of immunity and transmission probabilities by serotype, are unknown. We simulated GBS spread in a population using a computational model with parameters derived from studies of GBS sexual transmission in a college dormitory. Here we provide estimates of the duration of immunity relative to the transmission probabilities for the 3 GBS serotypes most associated with invasive disease: Ia, III, and V. We also place upper limits on the durations of immunity for serotype Ia (570 days), III (1125 days) and V (260 days). Better transmission estimates are required to establish the epidemiological parameters of GBS infection and determine the best vaccination strategies to prevent GBS disease.
KW - Group B Streptococcus
KW - Modeling
KW - Streptococcus agalactiae
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=79960391089&partnerID=8YFLogxK
U2 - 10.1016/j.meegid.2011.05.005
DO - 10.1016/j.meegid.2011.05.005
M3 - Article
C2 - 21605704
AN - SCOPUS:79960391089
SN - 1567-1348
VL - 11
SP - 1407
EP - 1412
JO - Infection, Genetics and Evolution
JF - Infection, Genetics and Evolution
IS - 6
ER -