Transmission of influenza B viruses in the Guinea pig

Natalie Pica, Yi Ying Chou, Nicole M. Bouvier, Peter Palese

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Epidemic influenza is typically caused by infection with viruses of the A and B types and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses can replicate in the upper respiratory tract of the guinea pig and that viruses of the two main lineages can be transmitted with 100% efficiency between inoculated and naïve animals in both contact and noncontact models. Our results also indicate that, like in the case for influenza A virus, transmission of influenza B viruses is enhanced at colder temperatures, providing an explanation for the seasonality of influenza epidemics in temperate climates. We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission.

Original languageEnglish
Pages (from-to)4279-4287
Number of pages9
JournalJournal of Virology
Issue number8
StatePublished - Apr 2012


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