Transmission of factor VII deficiency through liver transplantation

Stephen R. Guy, Joseph F. Magliocca, Steven Fruchtman, Patricia McDonough, Sukru Emre, Leona Kim-Schluger, Patricia A. Sheiner, Thomas M. Fishbein, Myron E. Schwartz, Charles M. Miller

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.

Original languageEnglish
Pages (from-to)278-280
Number of pages3
JournalTransplant International
Issue number4
StatePublished - Jul 1999


  • Factor VII deficiency, liver transplantation
  • Liver transplantation, disease transmission
  • Liver transplantation, factor VII deficiency


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