Transmission of factor VII deficiency through liver transplantation

Stephen R. Guy; Joseph F. Magliocca; Steven Fruchtman; Patricia McDonough; Sukru Emre; Leona Kim-Schluger; Patricia A. Sheiner; Thomas M. Fishbein; Myron E. Schwartz; Charles M. Miller

doi:10.1007/s001470050223

Transmission of factor VII deficiency through liver transplantation

Stephen R. Guy, Joseph F. Magliocca, Steven Fruchtman, Patricia McDonough, Sukru Emre, Leona Kim-Schluger, Patricia A. Sheiner, Thomas M. Fishbein, Myron E. Schwartz, Charles M. Miller

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.

Original language	English
Pages (from-to)	278-280
Number of pages	3
Journal	Transplant International
Volume	12
Issue number	4
DOIs	https://doi.org/10.1007/s001470050223
State	Published - Jul 1999

Keywords

Factor VII deficiency, liver transplantation
Liver transplantation, disease transmission
Liver transplantation, factor VII deficiency

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10.1007/s001470050223

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title = "Transmission of factor VII deficiency through liver transplantation",

abstract = "The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.",

keywords = "Factor VII deficiency, liver transplantation, Liver transplantation, disease transmission, Liver transplantation, factor VII deficiency",

author = "Guy, {Stephen R.} and Magliocca, {Joseph F.} and Steven Fruchtman and Patricia McDonough and Sukru Emre and Leona Kim-Schluger and Sheiner, {Patricia A.} and Fishbein, {Thomas M.} and Schwartz, {Myron E.} and Miller, {Charles M.}",

year = "1999",

month = jul,

doi = "10.1007/s001470050223",

language = "English",

volume = "12",

pages = "278--280",

journal = "Transplant International",

issn = "0934-0874",

publisher = "European Society for Organ Transplantation",

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TY - JOUR

T1 - Transmission of factor VII deficiency through liver transplantation

AU - Guy, Stephen R.

AU - Magliocca, Joseph F.

AU - Fruchtman, Steven

AU - McDonough, Patricia

AU - Emre, Sukru

AU - Kim-Schluger, Leona

AU - Sheiner, Patricia A.

AU - Fishbein, Thomas M.

AU - Schwartz, Myron E.

AU - Miller, Charles M.

PY - 1999/7

Y1 - 1999/7

N2 - The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.

AB - The liver is the primary site of synthesis for the majority of coagulation factors. There are published accounts of liver donor-to-recipient transmission of protein C deficiency with dysfibrinogenemia and factor XI deficiency. In this article, we report what we believe to be the first observation, of transmission of factor VII deficiency, a rare, autosomal recessive coagulation disorder, from an affected liver donor to a naive liver recipient. At 300 days after transplantation, the recipient remains with an isolated prolongation of the prothrombin time and a below-normal level of factor VII, and has had no bleeding complications.

KW - Factor VII deficiency, liver transplantation

KW - Liver transplantation, disease transmission

KW - Liver transplantation, factor VII deficiency

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DO - 10.1007/s001470050223

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VL - 12

SP - 278

EP - 280

JO - Transplant International

JF - Transplant International

IS - 4

ER -

Transmission of factor VII deficiency through liver transplantation

Abstract

Keywords

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