Translocation (3;21) in Philadelphia chromosome—positive chronic myelogenous leukemia prior to the onset of blast crisis

Thomas Coyle, Vesna Najfeld

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Two female patients in the chronic phase of CML were found to have, in addition to t(9;22), a new karyotypic abnormality—t(3;21)(q26;q22)—present in bone marrow cells. At diagnosis, this abnormality was observed in a small number of marrow cells in both patients, and as the disease progressed in patient 1, the percentage of cells showing t(3;21) was increased, reaching 100% as the transformation to blast crisis occurred. These observations suggest that t(3;21) may represent a new and rare nonrandom rearrangement which may be identified prior to the onset of blast crisis.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalAmerican Journal of Hematology
Volume27
Issue number1
DOIs
StatePublished - Jan 1988

Keywords

  • CML
  • Ph‐positive
  • t(3;21)

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