Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers

Manon Jaud, Céline Philippe, Doriana Di Bella, Weiwei Tang, Stéphane Pyronnet, Henrik Laurell, Laurent Mazzolini, Kevin Rouault-Pierre, Christian Touriol

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

During carcinogenesis, almost all the biological processes are modified in one way or another. Among these biological processes affected, anomalies in protein synthesis are common in cancers. Indeed, cancer cells are subjected to a wide range of stresses, which include physical injuries, hypoxia, nutrient starvation, as well as mitotic, oxidative or genotoxic stresses. All of these stresses will cause the accumulation of unfolded proteins in the Endoplasmic Reticulum (ER), which is a major organelle that is involved in protein synthesis, preservation of cellular homeostasis, and adaptation to unfavourable environment. The accumulation of unfolded proteins in the endoplasmic reticulum causes stress triggering an unfolded protein response in order to promote cell survival or to induce apoptosis in case of chronic stress. Transcription and also translational reprogramming are tightly controlled during the unfolded protein response to ensure selective gene expression. The majority of stresses, including ER stress, induce firstly a decrease in global protein synthesis accompanied by the induction of alternative mechanisms for initiating the translation of mRNA, later followed by a translational recovery. After a presentation of ER stress and the UPR response, we will briefly present the different modes of translation initiation, then address the specific translational regulatory mechanisms acting during reticulum stress in cancers and highlight the importance of translational control by ER stress in tumours.

Original languageEnglish
Article number169
JournalCells
Volume9
Issue number3
DOIs
StatePublished - 26 Feb 2020
Externally publishedYes

Keywords

  • ER stress
  • translation initiation
  • uORF
  • unfolded protein response (UPR), IRES

Fingerprint

Dive into the research topics of 'Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers'. Together they form a unique fingerprint.

Cite this