Translational neuroimaging: Positron emission tomography studies of monoamine oxidase

Joanna S. Fowler; Jean Logan; Nora D. Volkow; Gene Jack Wang

doi:10.1007/s11307-005-0016-1

Translational neuroimaging: Positron emission tomography studies of monoamine oxidase

Joanna S. Fowler, Jean Logan, Nora D. Volkow, Gene Jack Wang

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs.

Original language	English
Pages (from-to)	377-387
Number of pages	11
Journal	Molecular Imaging and Biology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1007/s11307-005-0016-1
State	Published - Nov 2005
Externally published	Yes

Keywords

Brain
Monoamine oxidase
PET
Tobacco smoke

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@article{c29f6278395d4c6d9feafaca5ce42ff1,

title = "Translational neuroimaging: Positron emission tomography studies of monoamine oxidase",

abstract = "Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs.",

keywords = "Brain, Monoamine oxidase, PET, Tobacco smoke",

author = "Fowler, {Joanna S.} and Jean Logan and Volkow, {Nora D.} and Wang, {Gene Jack}",

note = "Funding Information: Acknowledgments. This work was supported by the United States Department of Energy (Office of Biological and Environmental Research; DE-AC02-98CH10886) and National Institutes of Health (National Institute for Biomedical Imaging and Bioengineering, EB2630 and National Institute on Drug Abuse, K 05 DA020001 and General Clinical Research Center, MO1RR10710).",

year = "2005",

month = nov,

doi = "10.1007/s11307-005-0016-1",

language = "English",

volume = "7",

pages = "377--387",

journal = "Molecular Imaging and Biology",

issn = "1536-1632",

publisher = "Springer New York",

number = "6",

}

TY - JOUR

T1 - Translational neuroimaging

T2 - Positron emission tomography studies of monoamine oxidase

AU - Fowler, Joanna S.

AU - Logan, Jean

AU - Volkow, Nora D.

AU - Wang, Gene Jack

N1 - Funding Information: Acknowledgments. This work was supported by the United States Department of Energy (Office of Biological and Environmental Research; DE-AC02-98CH10886) and National Institutes of Health (National Institute for Biomedical Imaging and Bioengineering, EB2630 and National Institute on Drug Abuse, K 05 DA020001 and General Clinical Research Center, MO1RR10710).

PY - 2005/11

Y1 - 2005/11

N2 - Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs.

AB - Positron emission tomography (PET) using radiotracers with high molecular specificity is an important scientific tool in studies of monoamine oxidase (MAO), an important enzyme in the regulation of the neurotransmitters dopamine, norepinephrine, and serotonin as well as the dietary amine, tyramine. MAO occurs in two different subtypes, MAO A and MAO B, which have different substrate and inhibitor specificity and which are different gene products. The highly variable subtype distribution with different species makes human studies of special value. MAO A and B can be imaged in the human brain and certain peripheral organs using PET and carbon-11 (half-life 20.4 minutes) labeled mechanism-based irreversible inhibitors, clorgyline and L-deprenyl, respectively. In this article we introduce MAO and describe the development of these radiotracers and their translation from preclinical studies to the investigation of variables affecting MAO in the human brain and peripheral organs.

KW - Brain

KW - Monoamine oxidase

KW - PET

KW - Tobacco smoke

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U2 - 10.1007/s11307-005-0016-1

DO - 10.1007/s11307-005-0016-1

M3 - Review article

C2 - 16265597

AN - SCOPUS:33644855958

SN - 1536-1632

VL - 7

SP - 377

EP - 387

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

IS - 6

ER -

Translational neuroimaging: Positron emission tomography studies of monoamine oxidase

Abstract

Keywords

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