Translational imaging: Imaging of apoptosis

H. William Strauss, Francis Blankenberg, Jean Luc Vanderheyden, Jonathan Tait

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

16 Scopus citations

Abstract

Since its original description in 1972, apoptosis or programmed cell death has been recognized as the major pathway by which the body precisely regulates the number and type of its cells as part of normal embryogenesis, development, and homeostasis. Later it was found that apoptosis was also involved in the pathogenesis of a number of human diseases, cell immunity, and the action of cytotoxotic drugs and radiation therapy in cancer treatment. As such, the imaging of apoptosis with noninvasive techniques such as with radiotracers, including annexin V and lipid proton magnetic resonance spectroscopy, may have a wide range of clinical utility in both the diagnosis and monitoring therapy of a wide range of human disorders. In this chapter we review the basic biochemical and morphologic features of apoptosis and the methods developed thus far to image this complex process in humans.

Original languageEnglish
Title of host publicationMolecular Imaging II
PublisherSpringer Science and Business Media, LLC
Pages259-275
Number of pages17
EditionPART2
ISBN (Print)9783540774495
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
NumberPART2
Volume185
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

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