Translating the low translaminar cribrosa pressure gradient hypothesis into the clinical care of glaucoma

Ann H. Guy, Janey L. Wiggs, Angela Turalba, Louis R. Pasquale

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Glaucoma is an optic neuropathy with multiple known risk factors, including age, race, family history, and intraocular pressure. Unfortunately, the only currently modifiable risk factor in treating the disease is intraocular pressure (IOP). Recent studies have investigated intracranial pressure (ICP) and the translaminar cribrosa pressure gradient as a potential explanation for glaucomatous optic nerve vulnerability across a range of IOP values. The difference between these two pressures across the lamina cribrosa may have an effect on the optic nerve, which could provide another modifiable parameter in the battle against glaucoma. In order for modification of the translaminar pressure gradient to be considered in the treatment of glaucoma, noninvasive methods to accurately measure ICP need to be developed. The translaminar pressure gradient could be therapeutically adjusted by either further lowering the IOP or raising the ICP when it is pathologically low, if possible.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalSeminars in Ophthalmology
Volume31
Issue number1-2
DOIs
StatePublished - 3 Mar 2016
Externally publishedYes

Keywords

  • Intracranial pressure
  • Intraocular pressure
  • Primary open angle glaucoma

Fingerprint

Dive into the research topics of 'Translating the low translaminar cribrosa pressure gradient hypothesis into the clinical care of glaucoma'. Together they form a unique fingerprint.

Cite this