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Transition state analogue of MTAP extends lifespan of APC
Min/+
mice
Ross S. Firestone
, Mu Feng
, Indranil Basu
, Karina Peregrina
, Leonard H. Augenlicht
, Vern L. Schramm
Icahn School of Medicine at Mount Sinai
Research output
:
Contribution to journal
›
Article
›
peer-review
13
Scopus citations
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Min/+
mice'. Together they form a unique fingerprint.
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Keyphrases
Methylthioadenosine Phosphorylase
100%
Methylthioadenosine
100%
Transition State Analogue
100%
Methylthiol
61%
Familial Adenomatous Polyposis
30%
S-adenosylmethionine
23%
Protein Arginine Methyltransferase 5 (PRMT5)
23%
MAT2A
23%
Mouse Model
15%
Methionine
15%
Methylation
7%
Anemia
7%
Tumor
7%
Lung
7%
Pharmacological Inhibitors
7%
Murine Model
7%
Tumor Growth
7%
Cancer Cell Lines
7%
Colectomy
7%
Physiologic
7%
ATP Level
7%
Monotherapy
7%
Colorectal Cancer
7%
Head-and-neck
7%
Polyamines
7%
Human Head
7%
Transferases
7%
Immunodeficient Mice
7%
Genome Analysis
7%
Anticancer Effect
7%
A549
7%
Immunohistochemical Analysis
7%
Intestinal Tissue
7%
Duodenal Tumor
7%
Salvage Pathway
7%
Oral Dosing
7%
Resistant Cell Lines
7%
Anticancer Therapeutics
7%
Methylation Reaction
7%
Human Neck
7%
Synthetic Lethal Interaction
7%
Transition State Inhibitors
7%
Polyamine Synthesis
7%
Methionine Level
7%
FaDu
7%
Symmetric Dimethylarginine
7%
Intestinal Adenoma
7%
Medicine and Dentistry
Lifespan
100%
5' Methylthioadenosine Phosphorylase
100%
Galidesivir
88%
Familial Adenomatous Polyposis
44%
S-Adenosyl Methionine
33%
Methylation
22%
Malignant Neoplasm
22%
Oral
22%
Anemia
11%
Monotherapy
11%
Cancer
11%
Tumor Progression
11%
Neck
11%
Colectomy
11%
Colorectal Carcinoma
11%
Cancer Cell Line
11%
Methionine
11%
Duodenum Tumor
11%
Metabolomics
11%
Adenoma
11%
Adenosine Triphosphate
11%
Resistant Cell Line
11%
Tumor
11%
Polyamine
11%
Methionine Adenosyltransferase
11%
Polyamine Synthesis
11%
N(g),n(g) Dimethylarginine
11%
Lung
11%
Biochemistry, Genetics and Molecular Biology
Lifespan
100%
Phosphorylase
100%
Transition State Analog
100%
S-Adenosyl Methionine
44%
Methylation
22%
Mouse Model
22%
Anticancer
22%
Cancer Cell
11%
Enzyme
11%
Tumor Progression
11%
Metabolomics
11%
Adenosine Triphosphate
11%
Transferase
11%
Polyamine Synthesis
11%
Methionine
11%
Pharmacology, Toxicology and Pharmaceutical Science
5' Methylthioadenosine Phosphorylase
100%
Galidesivir
88%
Familial Adenomatous Polyposis
44%
Malignant Neoplasm
33%
S-Adenosyl Methionine
33%
Mouse Model
22%
Polyamine
22%
Anemia
11%
Monotherapy
11%
Tumor Growth
11%
Duodenum Tumor
11%
Adenosine Triphosphate
11%
Adenoma
11%
Colorectal Carcinoma
11%
Methionine
11%
6 N,n' Dimethylarginine
11%
N(g),n(g) Dimethylarginine
11%
Methionine Adenosyltransferase
11%