Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty

A. J. Conrad Smith; Robert E. Holt; Kelly Fitzpatrick; Igor F. Palacios; Herman K. Gold; Wendy Werner; Edwin G. Bovill; Valentin Fuster; Ik Kyung Jang

doi:10.1016/S0002-8703(96)90520-7

Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty

A. J. Conrad Smith, Robert E. Holt, Kelly Fitzpatrick, Igor F. Palacios, Herman K. Gold, Wendy Werner, Edwin G. Bovill, Valentin Fuster, Ik Kyung Jang

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Abstract

Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.

Original language	English
Pages (from-to)	434-439
Number of pages	6
Journal	American Heart Journal
Volume	131
Issue number	3
DOIs	https://doi.org/10.1016/S0002-8703(96)90520-7
State	Published - 1996

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title = "Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty",

abstract = "Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.",

author = "{Conrad Smith}, {A. J.} and Holt, {Robert E.} and Kelly Fitzpatrick and Palacios, {Igor F.} and Gold, {Herman K.} and Wendy Werner and Bovill, {Edwin G.} and Valentin Fuster and Jang, {Ik Kyung}",

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AU - Conrad Smith, A. J.

AU - Holt, Robert E.

AU - Fitzpatrick, Kelly

AU - Palacios, Igor F.

AU - Gold, Herman K.

AU - Werner, Wendy

AU - Bovill, Edwin G.

AU - Fuster, Valentin

AU - Jang, Ik Kyung

PY - 1996

Y1 - 1996

N2 - Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.

AB - Clinical and biochemical evidence of a rebound phenomenon after discontinuing thrombin inhibitors has been reported in patients with unstable angina. To investigate if a similar phenomenon occurs in patients undergoing coronary angioplasty, 14 patients were prospectively studied during and after discontinuation of heparin infusion. A transient thrombotic state identified by a significant increase in a polypeptide fragment and fibrinopeptide A was observed 3 hours after abruptly discontinuing heparin infusion. This observation may be clinically important in managing patients after coronary angioplasty.

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ER -

Transient thrombotic state after abrupt discontinuation of heparin in percutaneous coronary angioplasty

Abstract

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