Transient nigeal ubiquinone depletion after single MPTP administration in mice

R. G. Fariello; O. Ghirardi; A. Peschechera; M. T. Ramacci; L. Angelucci

doi:10.1016/0028-3908(87)90137-7

Transient nigeal ubiquinone depletion after single MPTP administration in mice

R. G. Fariello, O. Ghirardi, A. Peschechera, M. T. Ramacci, L. Angelucci

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Abstract

The administration of a single injection of 30 mg Kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 In the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system.

Original language	English
Pages (from-to)	1799-1802
Number of pages	4
Journal	Neuropharmacology
Volume	26
Issue number	12
DOIs	https://doi.org/10.1016/0028-3908(87)90137-7
State	Published - Dec 1987
Externally published	Yes

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title = "Transient nigeal ubiquinone depletion after single MPTP administration in mice",

abstract = "The administration of a single injection of 30 mg Kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 In the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system.",

author = "Fariello, {R. G.} and O. Ghirardi and A. Peschechera and Ramacci, {M. T.} and L. Angelucci",

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AU - Fariello, R. G.

AU - Ghirardi, O.

AU - Peschechera, A.

AU - Ramacci, M. T.

AU - Angelucci, L.

PY - 1987/12

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AB - The administration of a single injection of 30 mg Kg MPTP to mice produces at 1 hr, a transient significant decrease of the reduced ubiquinol Q10 In the substantia nigra that is normalized afterwards. This suggests a transient stress imposed by MPTP (or more likely MPP+) in the mitochondrial respiratory and/or oxidoreducing system, located in close proximity to the NADH system.

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Transient nigeal ubiquinone depletion after single MPTP administration in mice

Abstract

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