Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

Keyphrases

• Acute Myeloid Leukemia 100%
• Adoptive Cell Therapy 8%
• Antigen Exposure 8%
• Antigen Specificity 8%
• Antigen-specific 8%
• Antitumor Activity 8%
• Autologous T Cell 8%
• Bispecific T-cell Engager (BiTE) 41%
• CCR7 8%
• CD123 100%
• CD45RA 8%
• Cell Cytokines 8%
• Cell-like 8%
• Chimeric Antigen Receptor T Cells (CAR-T) 8%
• Chronic Antigenic Stimulation 8%
• Cytokine Production 8%
• Cytokine Profiling 8%
• Effector Cytokines 8%
• Effector Function 33%
• Granzyme B 8%
• Healthy Donors 8%
• Healthy Individuals 8%
• Immune Escape 8%
• Interleukin-15 (IL-15) 100%
• Liver 8%
• MIP-1b 8%
• Multiple Antigens 8%
• Nave 16%
• PDX Model 100%
• Perforin 8%
• Peripheral Blood 8%
• Peripheral Blood T Cells 8%
• Peripheral Tissues 8%
• Polyfunctional T Cells 8%
• Preclinical Evaluation 8%
• Relapsed or Refractory Acute Myeloid Leukemia 8%
• Retroviral Transduction 8%
• Spleen 8%
• Survival Benefit 8%
• T Cell Exhaustion 8%
• T Cell Persistence 8%
• T Cells 100%
• Transgenic Expression 100%
• Tumor Antigen 8%
• Xenograft Model 8%

Immunology and Microbiology

• Antigen Specificity 10%
• Antineoplastic Activity 5%
• CD123 Antigen 5%
• Chimeric Antigen Receptor 5%
• Coculture 5%
• Cytokine 5%
• Cytokine Production 5%
• Granzyme B 5%
• Immune Escape 5%
• Immunology 5%
• Immunostimulation 5%
• Immunotherapy 5%
• Myeloid 100%
• Perforin 5%
• T Cell 100%
• Transgenics 100%
• Tumor Antigen 5%
• Tumor Necrosis Factor 10%
• Xenograft 5%