TY - JOUR
T1 - Transgenic and infectious animal models of HIV-associated nephropathy
AU - Rosenstiel, Paul
AU - Gharavi, Ali
AU - D'Agati, Vivette
AU - Klotman, Paul
PY - 2009/11
Y1 - 2009/11
N2 - HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Transgenic and infectious models of HIVAN faithfully recapitulate the human disease and are important tools in advancing our understanding of disease pathogenesis, genetic susceptibility, and therapeutic intervention beyond the inhibition of viral replication. This review discusses the available transgenic murine models and infectious models of HIVAN in mice, rats, nonhuman primates, and felines. Particular emphasis is given to cell type-specific HIV expression as well as partial HIV genome expression used to map HIV-1 Nef and Vpr as pathologic determinants.
AB - HIV-associated nephropathy (HIVAN) is a major cause of HIV-related morbidity and mortality. Transgenic and infectious models of HIVAN faithfully recapitulate the human disease and are important tools in advancing our understanding of disease pathogenesis, genetic susceptibility, and therapeutic intervention beyond the inhibition of viral replication. This review discusses the available transgenic murine models and infectious models of HIVAN in mice, rats, nonhuman primates, and felines. Particular emphasis is given to cell type-specific HIV expression as well as partial HIV genome expression used to map HIV-1 Nef and Vpr as pathologic determinants.
UR - http://www.scopus.com/inward/record.url?scp=72049094063&partnerID=8YFLogxK
U2 - 10.1681/ASN.2008121230
DO - 10.1681/ASN.2008121230
M3 - Short survey
C2 - 19497967
AN - SCOPUS:72049094063
SN - 1046-6673
VL - 20
SP - 2296
EP - 2304
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
IS - 11
ER -