Transfusion-Associated Circulatory Overload and Transfusion-Related Acute Lung Injury

Tayler A. Van Den Akker, Zachary M. Grimes, Mark T. Friedman

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Objectives: To review the new current diagnostic criteria of transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) from the literature while highlighting distinguishing features. We provide comprehensive understanding of the importance of hemovigilance and its role in appropriately identifying and reporting these potentially fatal transfusion reactions. Methods: A review of the English language literature was performed to analyze TACO and TRALI while providing further understanding of the rationale behind the historical underrecognition and underreporting. Results: Our review demonstrates the new 2018 and 2019 case definitions for TACO and TRALI, respectively. With more comprehensive diagnostic strategies, adverse transfusion events can be better recognized from mimicking events and underlying disease. In addition, there are mitigation strategies in place to help prevent complications of blood product transfusion, with emphasis on the prevention of TACO and TRALI. Conclusions: TACO and TRALI are potentially fatal adverse complications of blood transfusion. Both have been historically underrecognized and underreported due to poor defining criteria and overlapping symptomatology. Developing a thorough clinical understanding between these two entities can improve hemovigilance reporting and can contribute to risk factor identification and preventative measures.

Original languageEnglish
Pages (from-to)529-539
Number of pages11
JournalAmerican Journal of Clinical Pathology
Issue number4
StatePublished - 1 Oct 2021
Externally publishedYes


  • ARDS
  • Hemovigilance
  • TACO
  • Transfusion reaction


Dive into the research topics of 'Transfusion-Associated Circulatory Overload and Transfusion-Related Acute Lung Injury'. Together they form a unique fingerprint.

Cite this