TY - JOUR
T1 - Transformed bone marrow cells generate neoplasms of distinct histogenesis. a murine model of cancer transplantation
AU - Castillo-Martin, Mireia
AU - Gladoun, Nataliya
AU - Han, Dan
AU - Firpo-Betancourt, Adolfo
AU - Silva, Jose M.
AU - Cordon-Cardo, Carlos
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/12
Y1 - 2019/12
N2 - The last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, but solid neoplasms may also develop, which in certain instances are donor-derived. It has also been well documented that multipotent bone marrow derived cells can migrate to diverse organs, differentiating into various histological lineages. The present study reports an experimental syngeneic transplantation model, using fluorescently tagged bone marrow cells from p53 null male mice into female wild-type counterparts. We found that transplanted non-neoplastic mutant bone marrow cells can generate tumors of distinct histogenesis, including thymic lymphomas, sarcomas, and carcinomas after carcinogen induction, providing evidence that multipotent cancer-prone stem cells can reside in the bone marrow and are transplantable.
AB - The last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, but solid neoplasms may also develop, which in certain instances are donor-derived. It has also been well documented that multipotent bone marrow derived cells can migrate to diverse organs, differentiating into various histological lineages. The present study reports an experimental syngeneic transplantation model, using fluorescently tagged bone marrow cells from p53 null male mice into female wild-type counterparts. We found that transplanted non-neoplastic mutant bone marrow cells can generate tumors of distinct histogenesis, including thymic lymphomas, sarcomas, and carcinomas after carcinogen induction, providing evidence that multipotent cancer-prone stem cells can reside in the bone marrow and are transplantable.
KW - Bone marrow transplant
KW - Cancer stem cells
KW - Donor-derived neoplasms
KW - P53 null mice
UR - http://www.scopus.com/inward/record.url?scp=85074761609&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2019.101637
DO - 10.1016/j.scr.2019.101637
M3 - Article
C2 - 31731181
AN - SCOPUS:85074761609
SN - 1873-5061
VL - 41
JO - Stem Cell Research
JF - Stem Cell Research
M1 - 101637
ER -