TY - JOUR
T1 - Transformation of polycythemia vera to acute nonlymphocytic leukemia accompanied by t(1;3)(p36;q21) karyotype
AU - Najfeld, Vesna
AU - Coyle, Thomas
AU - Berk, Paul D.
PY - 1988/7/15
Y1 - 1988/7/15
N2 - The case of a patient with a history of polycythemia vera and 46,XX karyotype who transformed into acute nonlymphocytic leukemia with 46,XX,t(1;3)(p36;q21) rearrangement is reported. Significant percentages of the circulating blasts in the peripheral blood were positive on immunocytochemical stains for megakaryocyte markers, anti-Factor VIII, and antiglycoprotein IIb/IIIa. On the basis of our studies and published reports, trilineage hematopoietic abnormalities and a poor response to therapy may represent typical features of patients with t(1;3).
AB - The case of a patient with a history of polycythemia vera and 46,XX karyotype who transformed into acute nonlymphocytic leukemia with 46,XX,t(1;3)(p36;q21) rearrangement is reported. Significant percentages of the circulating blasts in the peripheral blood were positive on immunocytochemical stains for megakaryocyte markers, anti-Factor VIII, and antiglycoprotein IIb/IIIa. On the basis of our studies and published reports, trilineage hematopoietic abnormalities and a poor response to therapy may represent typical features of patients with t(1;3).
UR - http://www.scopus.com/inward/record.url?scp=0023764876&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(88)90029-5
DO - 10.1016/0165-4608(88)90029-5
M3 - Article
C2 - 3383167
AN - SCOPUS:0023764876
SN - 0165-4608
VL - 33
SP - 193
EP - 200
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -