@article{66fb0f23561f4da4b02710987b0f162b,
title = "Transethnic genome-wide scan identifies novel Alzheimer's disease loci",
abstract = "Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)–based tests (P < 5 × 10−8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10−6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10−6). Discussion Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.",
keywords = "APOE interaction, Alzheimer's disease, Genome-wide association, Transethnic",
author = "{Alzheimer's Disease Genetics Consortium} and Jun, {Gyungah R.} and Jaeyoon Chung and Logue, {Mark W.} and Richard Sherva and Farrer, {Lindsay A.} and Jesse Mez and Robert Barber and Beecham, {Gary W.} and Hamilton-Nelson, {Kara L.} and Kunkle, {Brian W.} and Martin, {Eden R.} and Pericak-Vance, {Margaret A.} and Bennett, {David A.} and Buxbaum, {Joseph D.} and Goate, {Alison M.} and Alison Goate and M. Carlos and Byrd, {Goldie S.} and Carrasquillo, {Minerva M.} and Nilufer Ertekin-Taner and Graff-Radford, {Neill R.} and Younkin, {Steven G.} and Crane, {Paul K.} and Shubhabrata Mukherjee and Timothy Thornton and Carlos Cruchaga and {De Jager}, Philip and Larson, {Eric B.} and Denis Evans and Fallin, {M. Danielle} and Foroud, {Tatiana M.} and Friedland, {Robert P.} and Hugh Hendrie and Hall, {Kathleen S.} and Rivka Inzelberg and Kamboh, {M. Ilyas} and Kauwe, {John S.K.} and Kukull, {Walter A.} and Adams, {Perrie M.} and Ryozo Kuwano and Albin, {Roger L.} and Apostolova, {Liana G.} and Manly, {Jennifer J.} and Vardarajan, {Badri N.} and Richard Mayeux and Barmada, {Michjael M.} and Barnes, {Lisa L.} and Beach, {Thomas G.} and Montine, {Thomas J.} and Mary Sano",
note = "Publisher Copyright: {\textcopyright} 2017 The Authors",
year = "2017",
month = jul,
day = "1",
doi = "10.1016/j.jalz.2016.12.012",
language = "English",
volume = "13",
pages = "727--738",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "John Wiley and Sons Inc.",
number = "7",
}