Transcriptomic Changes Highly Similar to Alzheimer’s Disease Are Observed in a Subpopulation of Individuals During Normal Brain Aging

Keyphrases

• Alzheimer's Disease 100%
• Late-onset Alzheimer's Disease 100%
• Healthy Brain Aging 100%
• Highly Similar 100%
• Transcriptomic Changes 100%
• Aging 69%
• Cognitively Normal 30%
• Alzheimer's Disease Brain 20%
• Gene Expression Changes 20%
• Older Individuals 20%
• Healthy Aging 20%
• Normal Aging 20%
• Transcriptomic Data 20%
• Brain Transcriptome 20%
• Methylation 10%
• Lipoproteins 10%
• Inflammatory Response 10%
• Hippocampus 10%
• Glycoprotein 10%
• Brain Regions 10%
• Molecular Events 10%
• Disease Development 10%
• Phosphoprotein 10%
• Cortical Regions 10%
• Disease-specific 10%
• Clinical Phenotype 10%
• Synapse 10%
• Alternative Splicing 10%
• Ion Transport 10%
• Acetylation 10%
• Transcript Level 10%
• Major Risk Factors 10%
• Shared Genetics 10%
• Synaptic Vesicle 10%
• Myelin Sheath 10%
• Aging Individuals 10%
• Young Donors 10%
• Normal Aging Brain 10%
• Transport Vesicles 10%
• Strong Interconnections 10%
• Cytoskeleton Genes 10%

Biochemistry, Genetics and Molecular Biology

• Transcriptomics 100%
• Gene Expression 66%
• Healthy Aging 66%
• Transcriptome 66%
• Methylation 33%
• Upregulation 33%
• Synapse 33%
• Glycoprotein 33%
• Phosphoprotein 33%
• Downregulation 33%
• Alternative Splicing 33%
• Ion Transport 33%
• Lipoprotein 33%
• Acetylation 33%
• Cytoskeleton 33%
• Downregulation and Upregulation 33%
• Myelin 33%

Neuroscience

• Alzheimer's Disease 100%
• Transcriptomics 100%
• Gene Expression 18%
• Transcriptome 18%
• Myelin 9%
• Hippocampus 9%
• Synapse 9%
• Ion Transport 9%
• Phosphoprotein 9%
• Glycoprotein 9%
• Synaptic Vesicle 9%
• Cytoskeleton 9%
• Alternative Splicing 9%
• Acetylation 9%
• Vesicular Transporter 9%
• Downregulation and Upregulation 9%
• Methylation 9%