TY - JOUR
T1 - Transcriptional augmentation
T2 - Modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements)
AU - Bode, Jürgen
AU - Benham, Craig
AU - Knopp, Angela
AU - Mielke, Christian
PY - 2000
Y1 - 2000
N2 - For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.
AB - For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.
KW - Base-unpairing region (BUR)
KW - Chromatin domains
KW - Episomal vectors
KW - Scaffold/matrix-attached regions
KW - Stress-induced duplex destabilization (SIDD)
KW - Transcriptional augmentation
KW - Unwinding elements (UE)
UR - https://www.scopus.com/pages/publications/0034103927
U2 - 10.1615/critreveukargeneexpr.v10.i1.90
DO - 10.1615/critreveukargeneexpr.v10.i1.90
M3 - Review article
C2 - 10813396
AN - SCOPUS:0034103927
SN - 1045-4403
VL - 10
SP - 73
EP - 90
JO - Critical Reviews in Eukaryotic Gene Expression
JF - Critical Reviews in Eukaryotic Gene Expression
IS - 1
ER -