TY - JOUR
T1 - Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses
AU - The Human Immunology Project Consortium (HIPC)
AU - Hagan, Thomas
AU - Gerritsen, Bram
AU - Tomalin, Lewis E.
AU - Fourati, Slim
AU - Mulè, Matthew P.
AU - Chawla, Daniel G.
AU - Rychkov, Dmitri
AU - Henrich, Evan
AU - Miller, Helen E.R.
AU - Diray-Arce, Joann
AU - Dunn, Patrick
AU - Lee, Audrey
AU - Deckhut-Augustine, A.
AU - Gottardo, R.
AU - Haddad, E. K.
AU - Hafler, D. A.
AU - Harris, E.
AU - Farber, D.
AU - Kleinstein, S. H.
AU - Levy, O.
AU - McElrath, J.
AU - Montgomery, R. R.
AU - Peters, B.
AU - Pulendran, Bali
AU - Rahman, A.
AU - Reed, E. F.
AU - Rouphael, N.
AU - Sarwal, M. M.
AU - Sékaly, R. P.
AU - Fernandez-Sesma, A.
AU - Sette, A.
AU - Stuart, K.
AU - Togias, A.
AU - Tsang, J. S.
AU - Levy, Ofer
AU - Gottardo, Raphael
AU - Sarwal, Minne M.
AU - Tsang, John S.
AU - Suárez-Fariñas, Mayte
AU - Sékaly, Rafick Pierre
AU - Kleinstein, Steven H.
N1 - Publisher Copyright:
© 2022, Springer Nature America, Inc.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses. Most vaccines induced signatures of innate immunity and plasmablasts at days 1 and 7, respectively, after vaccination. However, the yellow fever vaccine induced an early transient signature of T and B cell activation at day 1, followed by delayed antiviral/interferon and plasmablast signatures that peaked at days 7 and 14–21, respectively. Thus, there was no evidence for a ‘universal signature’ that predicted antibody response to all vaccines. However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses.
AB - Systems vaccinology has defined molecular signatures and mechanisms of immunity to vaccination. However, comparative analysis of immunity to different vaccines is lacking. We integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses. Most vaccines induced signatures of innate immunity and plasmablasts at days 1 and 7, respectively, after vaccination. However, the yellow fever vaccine induced an early transient signature of T and B cell activation at day 1, followed by delayed antiviral/interferon and plasmablast signatures that peaked at days 7 and 14–21, respectively. Thus, there was no evidence for a ‘universal signature’ that predicted antibody response to all vaccines. However, accounting for the asynchronous nature of responses, we defined a time-adjusted signature that predicted antibody responses across vaccines. These results provide a transcriptional atlas of immunity to vaccination and define a common, time-adjusted signature of antibody responses.
UR - http://www.scopus.com/inward/record.url?scp=85141100284&partnerID=8YFLogxK
U2 - 10.1038/s41590-022-01328-6
DO - 10.1038/s41590-022-01328-6
M3 - Article
C2 - 36316475
AN - SCOPUS:85141100284
SN - 1529-2908
VL - 23
SP - 1788
EP - 1798
JO - Nature Immunology
JF - Nature Immunology
IS - 12
ER -